منابع مشابه
Covalent lipid modifications of proteins
Is it fair to say that Micromalthus is an ancient, primitive beetle? Many of Micromalthus’ anatomical characters are indeed primitive, in the sense of resembling the most recent ancestor it shares with other beetles, but of course its life cycle is anything but. No one thinks the ancestral beetle — or the ancestors of any other living beetles — had Micromalthus’ bizarre genetic and developmenta...
متن کاملLipid modifications of proteins
Lipid modifications of proteins (Fig. 1) are widespread and functionally important in eukaryotic cells. For example, many intracellular proteins such as the signal-transducing heterotrimeric GTP-binding proteins (G proteins) and the Ras superfamily of G proteins are modified by 14or 16-carbon fatty acids and/or 15or 20-carbon isoprenoids. Also, a variety of cell surface proteins such as acetylc...
متن کاملSequencing covalent modifications of membrane proteins.
A number of strategies have successfully extended plant proteomics into the bilayer domain. Important benefits can be afforded by including a well-resolved intact protein mass spectrum alongside peptide identification experiments; recent studies of thylakoid membranes have yielded new information on the primary structure and covalent post-translational modification of many of the integral prote...
متن کاملMini-Review The Covalent Modification of Eukaryotic Proteins with Lipid
surprisingly large number of proteins in eukaryotic ceils are now known to contain covalently bound lipid. Several cell surface proteins, the Thy-1 glycoprotein (27, 55), acetylcholinesterase (14), alkaline phosphatase (28), and the variant surface glycoprotein of trypanosomes (13), among others, are anchored to the outer cell surface by a complex, glycosylated phospholipid (Table I; Fig. 1). A...
متن کاملThe covalent modification of eukaryotic proteins with lipid
surprisingly large number of proteins in eukaryotic ceils are now known to contain covalently bound lipid. Several cell surface proteins, the Thy-1 glycoprotein (27, 55), acetylcholinesterase (14), alkaline phosphatase (28), and the variant surface glycoprotein of trypanosomes (13), among others, are anchored to the outer cell surface by a complex, glycosylated phospholipid (Table I; Fig. 1). A...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2013
ISSN: 0960-9822
DOI: 10.1016/j.cub.2013.04.024